Disodium cromoglycate and induced asthma.

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Effect of disodium cromoglycate on exercise-induced asthma.

In eight patients with exercise-induced asthma, disodium cromoglycate was found to produce a definite inhibition of the post-exercise fall in forced expiratory volume in one second. This effect may be part of the cause for the subjective improvement experienced with this drug.

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Disodium cromoglycate in the prevention of induced asthma.

In 13 patients with allergic asthma disodium cromoglycate protected fully only two from an allergen-induced asthmatic attack.Inhalation of disodium cromoglycate did not improve lung function in five patients with long-standing chronic asthma.Previous clinical trials do not show convincing evidence that this drug improves bronchial asthma in a high percentage of cases, but it seems to help a sma...

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Comparison of actions of disodium cromoglycate and ketotifen on exercise-induced bronchoconstriction in childhood asthma.

Ketotifen (Zaditen), a benzocycloheptathiophene derivative, is a new oral agent for treating asthma, with action similar in some respects to that of sodium cromoglycate. It is well established that sodium cromoglycate protects against antigen challenge by inhibiting the release of chemical mediators from mast cells. It also inhibits exerciseinduced bronchoconstriction and has bronchodilator pro...

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Disodium cromoglycate can inhibit virus-induced cytopathic effects in vitro.

Investigations showed: haemoglobin 12 8 g/dl; white cell count 11 3 x 109!l (11 300/mm3), with 15 % eosinophils; blood urea 10-3 mmol/I (62 mg/ 100 ml); blood glucose 5-4 mmol/l (98 mg/100 ml); and serum sodium 129 mmol(mEq)/l, potassium 5-2 mmol(mEq)/l, and chloride 97 mmol (mEq)/l. Chest and abdominal x-ray pictures were normal. Antinuclear factor and thyroid and parietal cell antibodies were...

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X-ray analysis of disodium cromoglycate.

Disodium cromoglycate (I; DSCG) was introduced in 1968 for the treatment of bronchial asthma. Evidence concerning its principal effects and possible mode of action has been described at some length in the recent literature (Cox, 1971 ; Cox & Altoanyan, 1970). Crystals of the compound exhibit a remarkable reversible water absorption (Cox, Woodard & McCrone, 1971), the number of water molecules p...

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ژورنال

عنوان ژورنال: BMJ

سال: 1969

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.5658.696-b